Bumetanide
Bumetanide Information

About Bumetanide

Bumetanide is a loop diuretic and a sulfonamide derivative. Bumetanide is used as an antihypertensive agent. It has a carboxyl group with a sulfamoyl moiety in the meta position. A halide or phenoxy substitution is present at carbon 4, and a substituted amino group is present at carbon 2 or 3. It increases the urination and decrease the amount of water retained in the body.Bumetanide is administered orally, intramuscularly or intravenously. Bumetanide is a sulfonamide-type loop diuretic used in the management of edema associated with congestive heart failure, cirrhosis, and renal disease such as nephrotic syndrome.

Indications

Bumetanide is primarily indicated in conditions like Congestive heart failure, Hypercalcaemia, Hypertension, Nephrotic syndrome, Oedema, Oliguria due to renal failure, Prohylaxis of acid aspiration in obstetric patients, Pulmonary edema.

Contraindication

Bumetanide is contraindicated in conditions like Gout,Renal failure,Anuria,Hepatic coma,Severe elecrolyte imbalance.

Side Effects

The severe or irreversible adverse effects of Bumetanide, which give rise to further complications include Encephalopathy, Ototoxicity.Bumetanide produces potentially life-threatening effects which include Hypersensitivity reactions, Electrolyte and volume depletion, Electrolyte disturbances, Volume disturbances. which are responsible for the discontinuation of Bumetanide therapy.The signs and symptoms that are produced after the acute overdosage of Bumetanide include Electrolyte imbalance, Volume depletion, Cardiovascular shock, Embolism, Thrombosis.The symptomatic adverse reactions produced by Bumetanide are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Headache, Nausea, Vomiting, Diarrhea, Abdominal pain, Dry mouth, Rashes, Hypotension, Musculoskeletal discomfort, Diaphoresis, Renal failure, Nipple tenderness, Premature ejaculation, Erectile dysfunction, Arthralgia, Ear pain.

Warnings

Bumetanide should be used with caution in patients with medical history, including any allergies (especially drug allergies), liver or kidney diseases, blood disorders or hearing impairments. Dizziness on standing may occur, to avoid dizziness or lightheadedness when rising from a seated or lying position, get up slowly. This medication should be used only when clearly needed during pregnancy or lactation. Caution is advised when this drug is used in the elderly patients.

High Risk Groups

Drug should not be given to Paediatrics, Pregnant Mothers, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.