Aztreonam
Aztreonam Information

About Aztreonam

Aztreonam is a monobactam antibiotic. It has a monocyclic ß lactam ring. Aztreonam is used to treat a wide variety of bacterial infections. Antibiotics require constant drug level in body for therapeutic effect. This is achieved by taking the drug at regular interval of time throughout the day and night as prescribed.Aztreonam is important to take the drug for the full time period as prescribed. If you discontinue the drug it may result in ineffective treatment. May be used cautiously in patients allergic to PENICILLINS and CEPHALOSPORINS.

Indications

Aztreonam is primarily indicated in conditions like Gonorrhoea, Gonorrhoea/cystitis, Infiltration anaesthesia (higher strengths for dental use only), Labor, Muscle relaxation (long duration) for surgery and intubation, Pyelonephritis, Respiratory tract infections, Septicaemia, Urinary tract infection, Zollinger-ellison syndrome.

Contraindication

Aztreonam is contraindicated in conditions like Hypersensitivity,Pregnancy.

Side Effects

The severe or irreversible adverse effects of Aztreonam, which give rise to further complications include Pseudomembranous colitis, Eosinophilia, Exfoliative dermatitis.Aztreonam produces potentially life-threatening effects which include Anaphylactic reactions. which are responsible for the discontinuation of Aztreonam therapy.The symptomatic adverse reactions produced by Aztreonam are more or less tolerable and if they become severe, they can be treated symptomatically, these include Nausea, Vomiting, Diarrhea, Urticaria, Thrombophlebitis, Elevation of liver enzymes, Reaction at injection site.

Warnings

Aztreonam should be used with caution in patients with penicillin hypersensitivity or cephalosporin hypersensitivity, because of the structural similarities of aztreonam to penicillin and cephalosporins, these patients are more susceptible to hypersensitivity reactions. Appropriate monitoring is recommended in case of kidney or liver impairment. Take appropriate measures in case of secondary infection.

High Risk Groups

Drug should not be given to Pregnant Mothers, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.