Atropine (Sulphate)
Atropine (Sulphate) Information

About Atropine (Sulphate)

Atropine is a parasympatholytic derivative of belladona plants (e.g., deadly nightshade). Chemically Atropine (Sulphate) is identified as 1aH, 5aH-Tropan-3a-ol (+/-)-tropate (ester) sulfate. Atropine (Sulphate) is a cholinergic antagonist. It relaxes muscles in the eye causing the pupil to dilate. Atropine (Sulphate) is a both central and peripheral muscarinic blocking agent.Atropine (Sulphate) is used intravenously in the treatment of bradycardia and anticholinesterase poisoning. its most common adverse effects include dry mouth, blurred vision, glaucoma and retention of urine

Indications

Atropine (Sulphate) is primarily indicated in conditions like Anesthesia, Arrhythmias after myocardial infarction, As an antidote to organophosphorous (insecticides) poisoning, Asthma, Cardiopulmonary resuscitation, Choroiditis, Control of muscarinic side-effects of neostigmine, Diarrhoea, Drying secretions, Dysenteries, Intra-operative bradycardia, Iridocyclitis, Irritable colon syndrome, Myocardial infarction, Peptic ulcer, Poisoning, Pyloric disease, Tetanus.

Contraindication

Atropine (Sulphate) is contraindicated in conditions like Glucoma,Reflux oesophagitis,Prostatic hypertrophy,Unstable cardiac rhythm.

Side Effects

The severe or irreversible adverse effects of Atropine (Sulphate), which give rise to further complications include Hallucinations, Confusion, Drowsiness, Restlessness, Delirium, Disturbance of speech.Atropine (Sulphate) produces potentially life-threatening effects which include Tachycardia, Cardiac arrhythmia, Atrioventricular dissociation, Multiple ventricular ectopics. which are responsible for the discontinuation of Atropine (Sulphate) therapy.The signs and symptoms that are produced after the acute overdosage of Atropine (Sulphate) include Flushing, Blurred vision, Constipation, Urinary hesitancy, Drowsiness, Dry mouth.The symptomatic adverse reactions produced by Atropine (Sulphate) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Thirst, Dry mouth, Mild blurring of vision.

Warnings

Closely monitor patients for therapeutic response and side effects. Atropine should not used in high dose because may produce mental depression or mental distrubances. It should be used with caution in patients over 40 years because may increase the risk of glaucoma. It should be used with caution in patients with asthma, heart or renal diseases. It should be used with caution in infants and children.

High Risk Groups

Drug should not be given to Paediatrics, Geriatrics, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.