Atenolol
Atenolol Information
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Atenolol
medicine,pricing, side effects of Atenolol medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Atenolol
Atenolol is a competitive,ß-1 selective adrenergic antagonist, similar to metoprolol. ß-adrenergic antagonists counter the effect of sympathomimetic neurotransmitters (i.e., catecholamines) by competing for receptor sites. Similar to metoprolol, it, in low doses, selectively blocks sympathetic stimulation mediated by ß-adrenergic receptors in the heart and vascular smooth muscle. It antagonizes ß1 receptors at doses 50 to 100 times less than those required to block ß2 receptors. This cardioselectivty is more pronounced at low doses and is lost at high doses. It lowers the blood pressure in hypertension and slows the heart rate.
Indications
Atenolol is primarily indicated in conditions like Angina, Angina pectoris, Cardiac arrhythmia, Early intervention within 12 hrs of myocardial infarction, Hypertension, Myocardial infarction, To prevent recurrence of neural tube defect, and can also be given in adjunctive therapy as an alternative drug of choice in Alcohol withdrawal, Migraine prophylaxis.
Contraindication
Atenolol is contraindicated in conditions like Asthma,Depression,Heart failure,Cardiogenic shock,Bronchitis,Second or third degree A-V block.
Side Effects
The severe or irreversible adverse effects of Atenolol, which give rise to further complications include Hypotension, Bronchospasm, Impotence, AV-block, Agranulocytosis, Hyperglycemia, Sinus bradycardia, Oculomucocutaneous syndrome.Atenolol produces potentially life-threatening effects which include Heart failure. which are responsible for the discontinuation of Atenolol therapy.The signs and symptoms that are produced after the acute overdosage of Atenolol include Bradycardia, Convulsions, Coma, Ventricular asystole.The symptomatic adverse reactions produced by Atenolol are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Fatigue, Alopecia, Diarrhea, Dyspnea, Cold extremities, Constipation, Insomnia, Pruritus, Impotence, Depression, Blood dyscrasias, Exfoliative dermatitis, Paresthesias, Hyperpigmentation, Wheezing, Vivid dreams, Xerosis.
Warnings
Atenolol should be used with caution in patients with poorly controlled diabetes mellitus particularly brittle diabetes, in patients with liver or kidney impairments, in hyperthyroidism or thyrotoxicosis because the drug can mask the tachycardia that occur in this condition. Abrupt withdrawal of atenolol in hyperthyroidism patient can precipitate a thyroid storm. Avoid abrupt withdrawal in angina patients. Use with caution during pregnancy.
High Risk Groups
Drug should not be given to Paediatrics, patients suffering from Kidney dysfunction, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Atenolol Dosage for Adults
| Dose | 2.5 mg |
| Single Dose | 2.5 (2.5) |
| Frequency | As recommended. |
| Route | IV |
| Note: At a rate of 1 mg/min | |
| Dose | 150 mcg/kg |
| Single Dose | 150 (150) |
| Frequency | As recommended. |
| Route | IV infusion |
| Note: Over 20 minutes. Maintenance dose 50-100 mg. | |
| Dose | 50 to 200 mg |
| Single Dose | 120 (125) |
| Frequency | 24 hourly |
| Route | PO |
Atenolol Dosage for Neonatal
| Dose | 1 to 2 mg/kg |
| Single Dose | 1.5 (1.5) |
| Frequency | 24 hourly |
| Route | oral |
| Note: Gradually increase the dose | |
| Dose | 1 to 2 mg/kg |
| Single Dose | 1.5 (1.5) |
| Frequency | 24 hourly |
| Route | Slow intravenous |
| Note: Gradually increase the dose |
Atenolol Dosage for Paedriatic
| Dose | 1 to 2 mg/kg |
| Single Dose | 1.5 (1.5) |
| Frequency | 24 hourly |
| Route | Oral |
| Note: - | |
| Dose | 1 to 2 mg/kg |
| Single Dose | 1.5 (1.5) |
| Frequency | 24 hourly |
| Route | Slow IV |
| Note: - |
Brands
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