Alfuzosin
Alfuzosin Information

About Alfuzosin

Alfuzosin is a competitive antagonist at the a1 adrenergic receptor, used for symptomatic relief in benign prostatic hypertrophy. Alfuzosin is optically active quinazolone derivative prepared by chemical synthesis. The racemate is used clinically. Alfuzosin is administered orally.

Indications

Alfuzosin is primarily indicated in conditions like Benign prostatic hyperplasia, and can also be given in adjunctive therapy as an alternative drug of choice in Hypertension.

Contraindication

Alfuzosin is contraindicated in conditions like Hypotension,Hypersensitivity,Hepatic insufficiency.

Side Effects

The symptomatic adverse reactions produced by Alfuzosin are more or less tolerable and if they become severe, they can be treated symptomatically, these include Dizziness, Vertigo, Headache, Nausea, Vomiting, Tachycardia, Skin rash, Postural hypotension, Syncope, dizziness.

Warnings

To avoid first dose effect i.e. marked postural hypotension and syncope, initial dose should be reduced and to be taken at the bed time.

High Risk Groups

Drug should not be given to Pregnant Mothers, and Neonates.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.