Alendronate (Na)
Alendronate (Na) Information
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Alendronate (Na)
medicine,pricing, side effects of Alendronate (Na) medicine by company and complete information of medicines in pakistan here on this page including all packings, MG, dosage information. This list includes medicines and drugs over every region of Pakistan like Karachi, Lahore, Islamabad, Faisalabad, Rawalpindi, Multan, Peshawar, Quetta and other cities of Pakistan.About Alendronate (Na)
Alendronate (Na) is aminobisphosphonate and inhibitor of osteoclast-mediated bone resorption. Chemically Alendronate (Na) is identified as (4-Amino-1-hydroxybutylidene)-bisphosphonic acid monosodium salt trihydtare. Alendronate (Na) is prepared by chemical synthesis. Alendronate (Na) is effective to treat osteoporosis (bone thinning) by increasing bone density in post menopausal women. At the cellular level, Alendronate (Na) shows preferential localization to sites of bone resorption, specifically under osteoclasts. The osteoclasts adhere normally to the bone surface but lack the ruffled border that is indicative of active resorption. Alendronate (Na) does not interfer with osteclast recruitment or attachment, but it does inhibit osteoclast activity. While incorporated in bone matrix, Alendronate (Na) is not pharmacologically active. Thus Alendronate (Na) must be continuously administered to suppress osteoclasts on newly formed resorption surface. Alendronate (Na) is administered orally.
Indications
Alendronate (Na) is primarily indicated in conditions like Osteoporosis in men, Osteoporosis prophylaxis, Pagets disease, Prevention and treatment of corticosteroid-induced osteoporosis, Treatment of osteoporosis in post menopausal women, and can also be given in adjunctive therapy as an alternative drug of choice in Hypercalcaemia associated with malignancy, Non-tumour induced hypercalcemia, Osteolytic tumoral bone disease.
Contraindication
Alendronate (Na) is contraindicated in conditions like Hypocalcaemia,Ulcers,Gastritis,Dysphagia,Vitamin D deficiency.
Side Effects
The severe or irreversible adverse effects of Alendronate (Na), which give rise to further complications include Peptic ulceration, Esophageal ulceration, Esophagus erosion.The symptomatic adverse reactions produced by Alendronate (Na) are more or less tolerable and if they become severe, they can be treated symptomatically, these include Headache, Nausea, Vomiting, Diarrhea, Constipation, Abdominal pain, Rashes, Gastritis, Heart burn, Dysphagia.
Warnings
Alendronate should be used with caution in patients with history of ulcers or any other gastrointestinal problems or difficulty in swallowing. Hypocalcemia must be corrected before initiating therapy with Alendorante, othere distrubances of mineral metabolism (such as vitamine D deficiency) should also be effectively treated. This medication should not be used by patients with more severe renal indufficiency with a creatinine clearance
High Risk Groups
Drug should not be given to Pregnant Mothers, and patients suffering from Kidney dysfunction.If prescribing authority justifies the benefits of the drug against the possible damages he/she should reevaluate them and consult the reference material and previous studies.
Dosage
Alendronate (Na) Dosage for Adults
| Dose | 10 mg |
| Single Dose | 10 (10) |
| Frequency | 24 hourly |
| Route | PO |
| Note: Must be taken atleast 1/2hr before the first food, beverage or medication of the day with plain water only. Patients should receive supplemental calcium and vitamin D, if dietary intake is inadequate. |
Alendronate (Na) Dosage for Neonatal
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| Single Dose | |
| Frequency | |
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| Note: Not recommended in this age group |
Alendronate (Na) Dosage for Paedriatic
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| Single Dose | |
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| Route | |
| Note: Not recommended in this age group |
Brands
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